International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (6): 535-540.doi: 10.3760/ cma.j.issn.1673-5803.2022.06.011

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Research progress of the relationship between angiopoietin-like 4 and the pathogenesis of neovascular ocular fundus disease

Wu Dongting1, Zheng Lei2, Zhang Guoming2   

  1. 1 The Second Clinical Medical College of Jinan University, Shenzhen 518020, China；2 Shenzhen Eye Hospital, Shenzhen Eye Hospital Affiliated to Jinan University, Shenzhen Eye Institute, Shenzhen 518040, China
  • Received:2022-08-21 Online:2022-12-22 Published:2022-12-22
  • Contact: Zhang Guoming, Email: 13823509060@163.com
  • Supported by:
     National Natural Science Foundation of China (82003794); Shenzhen Fund for Guangdong Provincial High-level Clinical Key Speciaties (SZGSP014); Shenzhen-Hong Kong Co-financing Project (SGDX20190920110403741); Shenzhen Key Medical Discipline Construction Fund (SZXK038); Basic Research of Shenzhen Science and Technology Plan Project (General Project) (JCYJ20190808 170609490)

Abstract: Angiopoietin-like 4 (ANGPTL4) is a recently discovered multifunctional protein involved in the regulation of glucose, lipid metabolism, angiogenesis, vascular permeability and other biological processes. ANGPTL4 is closely linked with the mechanism of neovascular ocular fundus disease such as diabetic retinopathy, retinal vascular occlusive disease, and age-related macular degeneration and so on. The expression of ANGPTL4 is up-regulated by high glucose and hypoxia, which induces a series of pathological events occurred including angiogenesis and increase vascular permeability. It is expected to become a diagnostic biomarker and potential therapeutic target for neovascular fundus diseases in the future. (Int Rev Ophthalmol, 2022, 46:  535-540)

Key words: angiopoietin-like 4, neovascular ocular fundus disease, angiogenic factor